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Cefaclor, the other second-generation oral prepara- Because of its inability to cross the blood brain barrier, tion, is inactivated by -lactamases produced by cefazolin should never be used to treat bacterial menin- H. Oral preparations are commonly used to treat less has been recommended for otitis media, other oral severe soft-tissue infections, including impetigo, early antibiotics are generally preferred. The half-lives of these Spectrum of Activity and Treatment Recommenda- agents vary, being as short as 1. They penetrate most increased activity against some gram-negative strains, body sites effectively. Improved activity against Haemophilus inuen- of this generation are ineffective for treating Enterococ- zae, Neisseria species, and Moraxella catarrhalis. A large number of iotetrazole ring that decreases prothrombin third-generation cephalosporins are available, all with production.

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